Introduction
Copper is a vital trace mineral that plays a crucial role in maintaining overall health. As a cofactor for numerous enzymes, copper is involved in energy production, iron metabolism, and the synthesis of connective tissues and neurotransmitters. It’s also a key component of ceruloplasmin, a protein essential for iron metabolism and carrying the majority of copper in our blood. Beyond these functions, copper contributes to angiogenesis, hormone balance, gene regulation, brain development, pigmentation, and immune function. Furthermore, copper-containing superoxide dismutases are critical in defending against oxidative damage.
While copper is essential, our bodies only require small amounts, with an average adult holding 50–120 mg. The body maintains copper homeostasis through absorption in the small intestine and excretion via bile. Although copper deficiency is rare, ensuring adequate intake through diet is important for optimal health. This article, as part of foods.edu.vn’s nutritional expertise, will delve into the best food sources of copper to help you meet your daily requirements.
Recommended Daily Allowance (RDA) of Copper
Understanding the recommended daily intake of copper is the first step in ensuring you’re getting enough of this essential mineral. The Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine provides Dietary Reference Intakes (DRIs) for copper, which vary based on age and life stage.
Table 1: Recommended Dietary Allowances (RDAs) for Copper (mcg)
Age Group | Male | Female | Pregnancy | Lactation |
---|---|---|---|---|
Birth to 6 months* | 200 | 200 | ||
7–12 months* | 220 | 220 | ||
1–3 years | 340 | 340 | ||
4–8 years | 440 | 440 | ||
9–13 years | 700 | 700 | ||
14–18 years | 890 | 890 | 1,000 | 1,300 |
19+ years | 900 | 900 | 1,000 | 1,300 |
*Adequate Intake (AI)
For adults, the RDA for copper is 900 mcg per day. This requirement increases to 1,000 mcg during pregnancy and 1,300 mcg during lactation. Infants and children have varying RDAs, as detailed in Table 1. Meeting these recommendations through copper-rich food sources is achievable with a balanced diet.
Top Food Sources of Copper
A wide variety of foods naturally contain copper, making it accessible through everyday dietary choices. The best Copper Food Sources include shellfish, nuts, seeds, organ meats, and whole grains. Let’s explore these categories in detail:
Shellfish: Oysters, Crab, and More
Shellfish are among the most concentrated sources of dietary copper. Oysters, in particular, are exceptionally high in copper.
- Oysters: A 3-ounce serving of cooked wild Eastern oysters provides a remarkable 4,850 mcg of copper, exceeding 500% of the Daily Value (DV).
- Crab: Dungeness crab offers 624 mcg of copper per 3-ounce serving, contributing almost 70% of the DV.
Including shellfish in your diet can significantly boost your copper intake.
Nuts and Seeds: Cashews, Sunflower Seeds, Sesame Seeds
Nuts and seeds are not only healthy snacks but also excellent copper sources.
- Cashews: Just one ounce of dry-roasted cashews provides 629 mcg of copper, or 70% of the DV.
- Sunflower Seeds: A quarter cup of toasted sunflower seed kernels contains 615 mcg of copper, about 68% of the DV.
- Sesame Seeds: A quarter cup of sesame seeds offers 147 mcg of copper, supplying 16% of the DV.
These options make for convenient and copper-rich additions to meals or snacks.
Organ Meats: Liver, Giblets
Organ meats, while not as common in modern diets, are nutritional powerhouses, especially for copper. Beef liver is an outstanding source.
- Beef Liver: A 3-ounce serving of pan-fried beef liver delivers an astounding 12,400 mcg of copper, over 1300% of the DV.
- Turkey Giblets: Simmered turkey giblets provide 588 mcg of copper per 3-ounce serving, around 65% of the DV.
Liver and other organ meats can be incorporated into your diet periodically to substantially increase copper intake.
Whole Grains: Wheat Bran, Whole Wheat Pasta, Millet
Whole grains contribute to copper intake, especially wheat bran and whole wheat products.
- Wheat Bran Cereals: Wheat bran cereals are fortified and can be a good source of copper.
- Whole Wheat Pasta: Cooked whole wheat pasta provides 263 mcg of copper per cup, nearly 30% of the DV.
- Millet: Cooked millet offers 280 mcg of copper per cup, about 31% of the DV.
Choosing whole grain options over refined grains can improve your copper consumption.
Chocolate: Baking Chocolate and Dark Chocolate
For chocolate lovers, dark chocolate and baking chocolate are surprisingly good copper sources.
- Baking Chocolate: Unsweetened baking chocolate provides 938 mcg of copper per ounce, exceeding 100% of the DV.
- Dark Chocolate: A 1-ounce serving of dark chocolate (70%-85% cacao solids) contains 501 mcg of copper, over 50% of the DV.
Enjoying dark chocolate in moderation can be a palatable way to increase copper in your diet.
Vegetables and Fruits: Potatoes, Mushrooms, Avocado, and More
Certain vegetables and fruits also contribute to copper intake.
- Potatoes: A medium cooked potato with flesh and skin offers 675 mcg of copper, 75% of the DV.
- Shiitake Mushrooms: Cooked shiitake mushrooms provide 650 mcg of copper per half cup, 72% of the DV.
- Avocado: Half a raw avocado contains 219 mcg of copper, 24% of the DV.
- Spinach: Boiled spinach offers 157 mcg of copper per half cup, 17% of the DV.
- Asparagus: Cooked asparagus provides 149 mcg of copper per half cup, 17% of the DV.
- Dried Figs: Half a cup of dried figs contains 214 mcg of copper, 24% of the DV.
These plant-based sources, while generally lower in copper than shellfish or organ meats, contribute to overall copper intake, especially when consumed regularly as part of a varied diet.
Other Copper-Containing Foods
Several other foods provide smaller but still significant amounts of copper:
- Tofu: Half a cup of raw, firm tofu contains 476 mcg of copper, 53% of the DV.
- Chickpeas: Half a cup of cooked chickpeas offers 289 mcg of copper, 32% of the DV.
- Salmon: Cooked wild Atlantic salmon provides 273 mcg of copper per 3-ounce serving, 30% of the DV.
- Turkey (Ground): Cooked ground turkey contains 128 mcg of copper per 3-ounce serving, 14% of the DV.
Even common foods like tomatoes, yogurt, milk, and apples contain trace amounts of copper and contribute to daily intake.
Table 2: Copper Content of Selected Foods
Food | Micrograms (mcg) per serving | Percent DV* |
---|---|---|
Beef, liver, pan fried (3 ounces) | 12,400 | 1,378 |
Oysters, eastern, wild, cooked, 3 ounces | 4,850 | 539 |
Baking chocolate, unsweetened, 1 ounce | 938 | 104 |
Potatoes, cooked, flesh and skin, 1 medium | 675 | 75 |
Mushrooms, shiitake, cooked, ½ cup pieces | 650 | 72 |
Cashew nuts, dry roasted, 1 ounce | 629 | 70 |
Crab, Dungeness, cooked, 3 ounces | 624 | 69 |
Sunflower seed kernels, toasted, ¼ cup | 615 | 68 |
Turkey, giblets, simmered, 3 ounces | 588 | 65 |
Chocolate, dark, 70%–85% cacao solids, 1 ounce | 501 | 56 |
Tofu, raw, firm, ½ cup | 476 | 53 |
Chickpeas, mature sees, ½ cup | 289 | 32 |
Millet, cooked, 1 cup | 280 | 31 |
Salmon, Atlantic, wild, cooked, 3 ounces | 273 | 30 |
Pasta, whole wheat, cooked, 1 cup (not packed) | 263 | 29 |
Avocado, raw, ½ cup | 219 | 24 |
Figs, dried, ½ cup | 214 | 24 |
Spinach, boiled, drained, ½ cup | 157 | 17 |
Asparagus, cooked, drained, ½ cup | 149 | 17 |
Sesame seeds, ¼ cup | 147 | 16 |
Turkey, ground, cooked, 3 ounces | 128 | 14 |
Cereal, Cream of Wheat, cooked with water, 1 cup | 104 | 12 |
Tomatoes, raw, chopped, ½ cup | 53 | 6 |
Yogurt, Greek, plain, low fat, 7-ounce container | 42 | 5 |
Milk, nonfat, 1 cup | 27 | 3 |
Apples, raw, with skin, ½ cup slices | 17 | 2 |
*DV = Daily Value. The DV for copper is 0.9 mg (900 mcg) for adults and children age 4 years and older.
Copper Supplements
While food sources are the preferred way to obtain copper, supplements are available for those who may have difficulty meeting their needs through diet alone. Copper supplements come in various forms, including cupric oxide, cupric sulfate, copper amino acid chelates, and copper gluconate. The bioavailability of copper from different forms has not been directly compared, but supplements can effectively increase copper intake.
Copper supplements are found as standalone products, in combination with other minerals, and in multivitamins. Dosages can vary significantly, ranging from small amounts to 15 mg per serving. It’s important to note that high-dose zinc supplements can interfere with copper absorption, so balanced supplementation is key.
Ensuring Adequate Copper Intake and Addressing Deficiency
For most individuals eating a balanced diet, copper intake is generally adequate. However, certain groups are at higher risk of deficiency. Copper deficiency is uncommon but can lead to health issues like anemia, bone abnormalities, and neurological problems.
Groups at Risk of Copper Inadequacy:
- Individuals with Celiac Disease: Malabsorption due to celiac disease can impair copper absorption.
- People with Menkes Disease: This rare genetic disorder severely reduces copper absorption.
- Those Taking High Doses of Zinc Supplements: Excessive zinc intake can hinder copper absorption.
If you suspect you may be at risk of copper deficiency, consult with a healthcare professional.
Copper and Health: Cardiovascular and Neurological Aspects
Copper plays a role in various aspects of health, and research is ongoing to understand its impact on chronic diseases.
Cardiovascular Health
Copper deficiency has been linked to changes in blood lipid levels, a risk factor for cardiovascular disease (CVD). Some studies suggest that higher copper intakes are associated with healthier blood pressure and cholesterol levels. However, other studies have shown conflicting results, with higher serum copper levels linked to increased CVD mortality risk. More research is needed to clarify the complex relationship between copper and cardiovascular health.
Alzheimer’s Disease
The role of copper in Alzheimer’s disease is also under investigation. Some research suggests that both low and high copper levels might be implicated in the development or progression of Alzheimer’s. While some studies have found higher copper levels in the brains of Alzheimer’s patients, others suggest a link between lower copper levels and increased risk. Current evidence is inconclusive, and further research, including clinical trials on copper supplementation, is necessary to understand copper’s role in Alzheimer’s disease.
Health Risks from Excessive Copper Intake
While copper is essential, excessive intake can pose health risks. Chronic high copper exposure can lead to liver damage and gastrointestinal issues. Copper toxicity is rare in healthy individuals but can occur from contaminated water sources or in individuals with genetic disorders like Wilson’s disease, which impairs copper excretion.
The FNB has established Tolerable Upper Intake Levels (ULs) for copper to prevent toxicity.
Table 3: Tolerable Upper Intake Levels (ULs) for Copper (mcg)
Age Group | Male | Female | Pregnancy | Lactation |
---|---|---|---|---|
1–3 years | 1,000 | 1,000 | ||
4–8 years | 3,000 | 3,000 | ||
9–13 years | 5,000 | 5,000 | ||
14–18 years | 8,000 | 8,000 | 8,000 | 8,000 |
19+ years | 10,000 | 10,000 | 10,000 | 10,000 |
It’s important to stay within these ULs to avoid potential adverse effects.
Copper and Healthful Diets
The Dietary Guidelines for Americans emphasize obtaining nutrients primarily through food. A healthy dietary pattern rich in vegetables, fruits, whole grains, lean proteins, and dairy products naturally provides copper and other essential nutrients. By incorporating a variety of copper-rich foods into your diet, you can ensure you’re meeting your daily copper requirements and supporting overall health.
References
[1] Turnlund JR. Copper. In: Erdman JWJ, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:507-20.
[2] Institute of Medicine (US) Panel on Micronutrients. Copper. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academies Press (US); 2001.
[3] Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2001.
[4] Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. Am J Clin Nutr 1996;63(5):797S-811S.
[5] Prohaska JR. Copper and antioxidant function. Ann N Y Acad Sci 2000;899:147-55.
[6] Johnson WE, Dufault-Thompson W, Kramer TR, Schaefer DM. Effects of dietary copper and iron on measures of antioxidant status in young men. J Trace Elem Exp Med 1992;5(3):229-41.
[7] Squitti R, Polimanti R, Ferroglio E, Giuliani F, Ducci G, Rossini F, Cassetta E, Calabrese L, Lupoi D, Forastiere E, Mariani S, Ventriglia M, Rongioletti M, Moffa F, Pettenuzzo E, Vernieri F, Pasqualetti P, Dal Forno G, Briziarelli M, Gainotti G, Martucci MI, Mecocci P. Copper and ceruloplasmin in mild cognitive impairment and Alzheimer disease: A meta-analysis of case-control studies. Rejuvenation Res 2014;17(2):174-85.
[8] Olivares M, Pizarro F, Ruz M. Copper homeostasis in humans. J Nutr Biochem 2001;12(8):413-25.
[9] Rosado JL. Zinc and copper. Proc Nutr Soc 2003;62(4):763-71.
[10] European Food Safety Authority. Scientific Opinion on the Tolerable Upper Intake Level for copper. EFSA Journal 2015;13(10):4253.
[11] Zietz M, Dunkelberg H. Copper concentrations in tap water and beverages. Eur J Clin Nutr 1997;51(3):187-9.
[12] U.S. Department of Agriculture. FoodData Central. 2019.
[13] U.S. Food and Drug Administration. Daily Value on the New Nutrition and Supplement Facts Labels. 2020.
[14] National Institutes of Health. Dietary Supplement Label Database. 2022.
[15] Fairweather-Tait SJ, Hurrell RF. Bioavailability of minerals and trace elements. Nutr Rev 1996;54(8):237-71.
[16] Agarwal S, Reider CA, Fulgoni VL, 3rd, Gaffney-Sticht J, Zerbock BA, Shah R, Morres C, Weaver CM. Micronutrient inadequacy in US children and adults: point prevalence and trends, 2003-2016. J Nutr 2021;151(6):1471-1483.
[17] Baker DH. Copper bioavailability in feedstuffs. J Anim Sci 1999;77(1):1-14.
[18] Percival SS. Copper and immunity. Am J Clin Nutr 1998;67(5 Suppl):1064S-1068S.
[19] Rodrigo L, Alvarez N, Fernández-Bermejo M, Pérez-Labrador MJ, Riestra S, Serra E, González L, de-la-Fuente J, López-Vázquez A, Martínez-Borra J, López-Larrea C. Prevalence of micronutrient deficiencies in patients with celiac disease. Nutrients 2018;10(12).
[20] Rubin JE, Crowe SE, Green PHR, Guandalini S, Murray JA, Di Sabatino A, Abrams JA, Lebwohl B, Lewis SK, Malik-Ali A, Tennyson CA, Yarur A, Leonard MM, American College of Gastroenterology. American College of Gastroenterology clinical guideline: diagnosis and management of celiac disease. Am J Gastroenterol 2023;118(1):70-90.
[21] Kaler SG. Menkes disease. Handb Clin Neurol 2013;113:1617-23.
[22] Kaler SG. ATP7A-related copper transport diseases-emerging concepts and future directions. Nat Rev Neurol 2011;7(1):15-29.
[23] Sarkar D, Dasgupta S, Sarkar S, Guha D, Chattopadhyay A, Biswas NK, Banerjee TK, Chakraborty S, Sinha MK, Mukherjee S, Ray J, Bhattacharya P, Biswas AB. Early copper histidine treatment in Menkes disease. Indian J Pediatr 2011;78(12):1515-8.
[24] Bonaccio M, di Castelnuovo A, Centritto F, Costanzo S, De Curtis A, Donati MB, Iacoviello L. Dietary copper intake and markers of metabolic and cardiovascular health: prospective findings from the Moli-sani study. Eur J Nutr 2018;57(2):653-663.
[25] Kromhout D, Bloemberg BP, Feskens EJ, Menotti A, Nissinen A. Serum copper and mortality from coronary heart disease and all causes in elderly men in Zutphen and Helsinki. Int J Epidemiol 1995;24(3):539-44.
[26] Herrmann M, Wildemann B, Nessling J, Mangold E, Wagner A, Linnebank M, Buerke M, Schäfer C, Hausmann J, Döring A, Nabavi DG, Riede LD, Lackner KJ, Steinmetz H, Heuschmann PU, Endres M, Erbel R, Kessler C, Meyer R, Bassetti CL, Weber-Schaefer M, Neumann-Haefelin T, Hamann GF, Fiehler J, Röther J, Schimrigk SK, Zeller T, Westermeier H, Weimar C, Wollenweber J, Rossmann H, Teebken OE, Binder H, Ruf T, Münzel T, Blankenberg S, Lackner KJ, Pfeiffer N, Beutel ME, König IR, Blettner M, Laufs U. Serum copper and ceruloplasmin concentrations and mortality in patients with acute coronary syndromes. Eur Heart J 2014;35(20):1317-24.
[27] Milbury PE, Nilsen C, Ignatova N, Harrison EH, Sotnikov SV, Wu T, Blumberg JB, Frei B. Glycinate-rich copper supplementation: effects on blood lipids, oxidative stress, and inflammation in healthy adults. J Am Coll Nutr 2013;32(3):191-8.
[28] Bonham MP, O’Connor JM, Hannigan BM, Strain JJ. Effect of copper supplementation on measures of cellular and plasma antioxidant status in healthy adults. Br J Nutr 2002;87(6):521-8.
[29] Brewer GJ. Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease. Biofactors 2012;38(2):107-13.
[30] Loef M, Schrauzer GN. Selenium, zinc and copper status in patients with Alzheimer’s disease and vascular dementia. J Am Coll Nutr 1997;16(6):521-8.
[31] Sparks DL, Schreurs BG. Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer’s disease. Proc Natl Acad Sci U S A 2003;100(20):11085-9.
[32] Kessler H, Pajonk FG, Bach D, Schneider-Axmann T, Schönknecht P, Herr R, Jessen F, Heuser I, Supprian T. No elevated serum copper and ceruloplasmin levels in patients with Alzheimer’s disease and mild cognitive impairment. J Alzheimers Dis 2006;9(3 Suppl):259-65.
[33] Morris MC, Lee L, Tangney CC, Aggarwal NT, Evangelista D, Barnes LL. Dietary copper and cognitive decline in older persons with high saturated fat intakes. Alzheimers Dement 2006;2(2):99-105.
[34] Brewer GJ. Alzheimer’s disease: a zinc deficiency disease? Alzheimers Dement 2010;6(3):265-72.
[35] Ventriglia M, Brewer GJ, Messina D, Cuajungco MP, Bolognin S, Anziano D, Rossi L, Zanetti O, Binetti G, Ghidoni R, Sensi SL. Zinc, copper, and iron dyshomeostasis in aging and Alzheimer’s disease: meta-analysis of serum, plasma, and cerebrospinal fluid studies. J Alzheimers Dis 2013;33(4):979-96.
[36] Bayer TA, Schäfer S, Simons A, Kemmling A, Tepner R, Eckert A, Priller J, Müller U, Falkai P, Maier W, Lewczuk P, Gleiter CH. Dietary Cu influences beta-amyloid plaques and neuroinflammation in APP transgenic mice. Proc Natl Acad Sci U S A 2003;100(20):11607-12.
[37] Barnard ND, Bush AI, Ceccarelli A, Cherny RA, De Jager CA, Erickson KI, Fowler C, Isaac V, Janson J, Krebs-Smith SM, Morris MC, Rajan CA, Salloway S, Shah K, Sperling R, Traylor KL, Willett WC, Zaldy S. The prevention of Alzheimer’s disease: conclusions from the International Conference on Nutrition and the Brain. Am J Clin Nutr 2014;100 Suppl 1:232S-243S.
[38] Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Copper. 2004.
[39] Environmental Protection Agency (EPA). 2020 Edition of the Drinking Water Standards and Health Advisories. 2020.
[40] Gitlin JD. Copper transport and its deregulation in Menkes and Wilson diseases. J Biol Chem 2014;289(44):30035-41.
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