Deliciously Rich in Copper: Unveiling the Best Foods to Boost Your Health

Copper, often overshadowed by more talked-about nutrients, is a true nutritional powerhouse that plays a vital role in maintaining your overall health. As an essential trace mineral, copper is naturally present in a variety of foods and is crucial for numerous bodily functions. From energy production to immune support, copper works tirelessly behind the scenes to keep you feeling your best. Let’s dive into the fascinating world of copper and explore the most delicious and readily available foods that can help you meet your daily needs.

The Mighty Mineral: Why Copper is Essential for Your Body

Copper is a cofactor for a multitude of enzymes, known as cuproenzymes, which are involved in critical processes throughout your body [1-3]. Think of copper as a key that unlocks the potential of these enzymes, allowing them to perform their jobs efficiently. These jobs include:

  • Energy Production: Copper is essential for the enzymes involved in cellular respiration, the process your body uses to convert food into energy. Without enough copper, you might feel sluggish and fatigued.
  • Iron Metabolism: Copper plays a crucial role in how your body uses iron. It’s necessary for the formation of red blood cells and helps transport iron around the body. This is why copper deficiency can sometimes lead to anemia.
  • Connective Tissue Synthesis: Copper is vital for creating collagen and elastin, the proteins that provide structure and elasticity to your skin, blood vessels, bones, and tendons.
  • Neurotransmitter Synthesis: Copper is involved in the production of neurotransmitters, the chemical messengers that allow your brain cells to communicate. These neurotransmitters are crucial for mood, cognition, and nerve function.
  • Antioxidant Defense: Copper is a key component of superoxide dismutases, powerful antioxidants that protect your cells against damage from harmful free radicals [5,6]. This antioxidant action is vital for preventing chronic diseases and maintaining youthful vitality.
  • Immune System Function: Copper supports a healthy immune system, helping your body fight off infections and stay resilient.

One of the most abundant cuproenzymes is ceruloplasmin (CP), which is responsible for carrying over 95% of the copper in your blood plasma [4]. This highlights copper’s systemic importance and how it’s transported throughout your body to perform its many tasks. Beyond these core functions, copper is also involved in angiogenesis (the formation of new blood vessels), hormone balance, gene regulation, brain development, pigmentation, and overall immune function [1].

With such a wide range of responsibilities, it’s clear that copper is not just another mineral; it’s a cornerstone of good health. The good news is that incorporating copper-rich foods into your diet is not only beneficial but also incredibly delicious.

How Much Copper Do You Need? Understanding Recommended Daily Intakes

To ensure you’re getting enough of this essential mineral, health organizations have established recommended daily intakes. These recommendations, known as Dietary Reference Intakes (DRIs), are developed by experts at the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine [3]. The DRIs provide guidelines for nutrient intake based on age and sex to meet the needs of healthy individuals.

Here are the Recommended Dietary Allowances (RDAs) for copper, which represent the average daily intake sufficient to meet the nutrient requirements of nearly all healthy individuals [3]:

Table 1: Recommended Dietary Allowances (RDAs) for Copper

Age Group RDA (mcg/day)
Birth to 6 months* 200
7–12 months* 220
1–3 years 340
4–8 years 440
9–13 years 700
14–18 years 890
19+ years 900
Pregnancy (14-50 years) 1000
Lactation (14-50 years) 1300

*Adequate Intake (AI) is established for these age groups.

For adults, the RDA for copper is 900 mcg per day. During pregnancy, this increases to 1000 mcg, and during lactation, it rises to 1300 mcg to support both the mother’s and baby’s needs.

It’s important to note that the Daily Value (DV) for copper, used on food labels to help you understand nutrient content in the context of a total diet, is also set at 900 mcg for adults and children aged 4 years and older [13]. Foods providing 20% or more of the DV are considered high sources of copper, but even smaller amounts contribute to your overall daily intake.

Meeting these recommendations is easier and more enjoyable than you might think, thanks to the wide variety of delicious foods naturally rich in copper. Let’s explore some of the top food sources of this vital mineral.

Top Food Sources of Copper: A Delicious Dive

Nature has generously provided us with a wealth of copper-rich foods, making it easy to incorporate this essential mineral into your daily diet. The best sources of dietary copper are diverse and flavorful, spanning various food groups, from seafood to nuts and even chocolate!

Here are some of the top food categories and specific examples that stand out as excellent sources of copper:

1. Shellfish: Ocean’s Copper Treasures

Shellfish are among the most concentrated sources of copper you can find. Oysters, in particular, are nutritional goldmines when it comes to copper.

Image of cooked oysters in shells, showcasing their rich copper content.

Oysters: A 3-ounce serving of cooked wild eastern oysters provides a whopping 4,850 mcg of copper, which is an astounding 539% of the Daily Value [12]. Whether you enjoy them raw, grilled, or in a stew, oysters are a luxurious and potent way to boost your copper intake.

2. Organ Meats: Nutrient-Dense Powerhouses

Organ meats, like liver, are nutritional powerhouses, packed with a wide array of vitamins and minerals, including exceptionally high levels of copper.

Image of pan-fried beef liver slices, highlighting its status as a top copper food.

Beef Liver: Pan-fried beef liver is a standout source of copper. Just 3 ounces deliver an incredible 12,400 mcg of copper, exceeding the DV by a massive 1,378% [12]. While liver might not be an everyday staple for everyone, incorporating it occasionally can significantly contribute to your copper needs. Turkey giblets are another good source, offering 588 mcg of copper per 3-ounce serving [12].

3. Nuts and Seeds: Crunchy Copper Boosters

Nuts and seeds are not only healthy snacks but also valuable sources of copper. They offer a convenient and tasty way to increase your intake of this mineral.

Image of dry roasted cashew nuts, emphasizing their role as a good source of copper.

Cashew Nuts: Dry-roasted cashew nuts provide 629 mcg of copper per ounce, contributing 70% of the DV [12]. Enjoy a handful as a snack, add them to trail mix, or sprinkle them on salads and stir-fries for a copper boost.
Sunflower Seeds: Toasted sunflower seed kernels offer 615 mcg of copper per ¼ cup, providing 68% of the DV [12]. These seeds are perfect for snacking, adding to yogurt or oatmeal, or incorporating into homemade granola.
Sesame Seeds: A ¼ cup of sesame seeds contains 147 mcg of copper, accounting for 16% of the DV [12]. Use sesame seeds to top bagels, salads, or Asian-inspired dishes, or enjoy tahini (sesame seed paste) as a dip or spread.

4. Chocolate: A Deliciously Decadent Source

For chocolate lovers, here’s some good news: chocolate, especially dark chocolate, is a surprisingly good source of copper!

Image of dark chocolate squares, showcasing its unexpected copper richness.

Unsweetened Baking Chocolate: Unsweetened baking chocolate leads the way with 938 mcg of copper per ounce, providing 104% of the DV [12]. While you might not eat baking chocolate directly, it’s a key ingredient in rich desserts.
Dark Chocolate (70%-85% cacao solids): Dark chocolate offers a more palatable way to enjoy copper. One ounce provides 501 mcg of copper, which is 56% of the DV [12]. Indulge in a square or two of dark chocolate as a treat while benefiting from its copper content.

5. Whole Grains: Copper in Your Carbs

While not as concentrated as some other sources, whole grains contribute to your copper intake, especially when consumed regularly as part of a balanced diet.

Image of cooked whole wheat pasta, highlighting whole grains as a source of copper.

Whole Wheat Pasta: Cooked whole wheat pasta provides 263 mcg of copper per cup (not packed), contributing 29% of the DV [12]. Swap refined pasta for whole wheat versions to boost your fiber and copper intake.
Wheat Bran Cereal: Wheat bran cereals are also good sources of copper, making breakfast a copper-boosting opportunity.
Millet: Cooked millet offers 280 mcg of copper per cup, providing 31% of the DV [12]. This versatile grain can be used in place of rice or quinoa.

6. Vegetables: Copper from the Earth

Certain vegetables also contribute to your copper intake, making them valuable additions to a copper-conscious diet.

Image of cooked shiitake mushrooms, emphasizing vegetables as copper sources.

Shiitake Mushrooms: Cooked shiitake mushrooms provide 650 mcg of copper per ½ cup of cut pieces, delivering 72% of the DV [12]. Add shiitake mushrooms to stir-fries, soups, or omelets for a flavorful copper boost.
Potatoes (with skin): A medium cooked potato, with both flesh and skin, offers 675 mcg of copper, accounting for 75% of the DV [12]. Enjoy baked, roasted, or mashed potatoes with the skin on to maximize their copper content.
Spinach: Boiled and drained spinach provides 157 mcg of copper per ½ cup, contributing 17% of the DV [12]. Include spinach in salads, smoothies, or as a side dish.
Asparagus: Cooked and drained asparagus offers 149 mcg of copper per ½ cup, providing 17% of the DV [12]. Grill, roast, or steam asparagus as a delicious and copper-containing vegetable.

Table 2: Copper Content of Selected Foods

Food Micrograms (mcg) per serving Percent DV*
Beef, liver, pan fried (3 ounces) 12,400 1,378
Oysters, eastern, wild, cooked, 3 ounces 4,850 539
Baking chocolate, unsweetened, 1 ounce 938 104
Potatoes, cooked, flesh and skin, 1 medium potato 675 75
Mushrooms, shiitake, cooked, cut pieces, ½ cup 650 72
Cashew nuts, dry roasted, 1 ounce 629 70
Crab, Dungeness, cooked, 3 ounces 624 69
Sunflower seed kernels, toasted, ¼ cup 615 68
Turkey, giblets, simmered, 3 ounces 588 65
Chocolate, dark, 70%–85% cacao solids, 1 ounce 501 56
Tofu, raw, firm, ½ cup 476 53
Chickpeas, mature sees, ½ cup 289 32
Millet, cooked, 1 cup 280 31
Salmon, Atlantic, wild, cooked, 3 ounces 273 30
Pasta, whole wheat, cooked, 1 cup (not packed) 263 29
Avocado, raw, ½ cup 219 24
Figs, dried, ½ cup 214 24
Spinach, boiled, drained, ½ cup 157 17
Asparagus, cooked, drained, ½ cup 149 17
Sesame seeds, ¼ cup 147 16
Turkey, ground, cooked, 3 ounces 128 14
Cereal, Cream of Wheat, cooked with water, stove top, 1 cup 104 12
Tomatoes, raw, chopped, ½ cup 53 6
Yogurt, Greek, plain, low fat, 7-ounce container 42 5
Milk, nonfat, 1 cup 27 3
Apples, raw, with skin, ½ cup slices 17 2

*DV = Daily Value. The U.S. Food and Drug Administration (FDA) developed DVs to help consumers compare the nutrient contents of foods and dietary supplements within the context of a total diet. The DV for copper is 0.9 mg (900 mcg) for adults and children age 4 years and older [13].

By incorporating a variety of these copper-rich foods into your meals and snacks, you can easily meet your daily copper requirements and enjoy a diverse and flavorful diet.

Copper Deficiency: When You’re Not Getting Enough

While copper is readily available in many foods, deficiency can occur, although it’s relatively uncommon in healthy individuals with balanced diets [2]. However, certain conditions and dietary patterns can increase the risk of copper inadequacy.

Copper deficiency can manifest in various symptoms, impacting different aspects of health. Based on research in animals and humans, the effects of copper deficiency can include [1,17,18]:

  • Anemia: Copper’s role in iron metabolism means deficiency can lead to anemia, characterized by fatigue and weakness.
  • Hypopigmentation: Copper is involved in pigmentation, so deficiency can cause changes in skin and hair color.
  • Hypercholesterolemia: Copper deficiency can affect cholesterol levels in the blood.
  • Connective Tissue Disorders: Weakened collagen and elastin due to copper deficiency can lead to problems with bones, blood vessels, and skin.
  • Osteoporosis and Bone Defects: Copper’s role in bone health means deficiency can contribute to bone weakness.
  • Abnormal Lipid Metabolism: Copper is involved in fat metabolism, and deficiency can disrupt this process.
  • Ataxia: This neurological condition, characterized by loss of coordination, can be a symptom of severe copper deficiency.
  • Increased Risk of Infection: A weakened immune system due to copper deficiency can increase susceptibility to infections.

Groups at Risk of Copper Inadequacy: Who Needs to Pay Extra Attention?

Certain groups of people are more susceptible to copper deficiency due to various factors. These include:

1. People with Celiac Disease

Celiac disease, an autoimmune disorder triggered by gluten, can damage the small intestine and impair nutrient absorption. Studies have shown that individuals with celiac disease are at a higher risk of copper deficiency due to malabsorption [19]. Even those adhering to a gluten-free diet can still experience some level of malabsorption. The American College of Gastroenterology recommends monitoring copper levels in individuals with celiac disease [20].

2. People with Menkes Disease

Menkes disease is a rare genetic disorder affecting copper metabolism. Individuals with this condition have difficulty absorbing copper from food, leading to severe copper deficiency from a very young age [1,21]. Menkes disease is characterized by failure to thrive, developmental delays, seizures, and other serious health issues. Early diagnosis and treatment with copper injections are crucial for improving outcomes [23].

3. People Taking High Doses of Zinc Supplements

Excessive zinc intake can interfere with copper absorption. High doses of zinc supplements, especially over extended periods, can lead to copper deficiency [3]. This is because zinc and copper compete for absorption in the body. The Tolerable Upper Intake Level (UL) for zinc is set at 40 mg per day for adults to minimize the risk of copper deficiency [1,3].

If you belong to any of these groups, it’s important to be mindful of your copper intake and discuss your nutrient status with a healthcare professional.

Copper and Health: Beyond Basic Needs

While preventing deficiency is crucial, research is also exploring the potential roles of copper in various aspects of health, including chronic diseases.

Cardiovascular Health

Copper’s involvement in maintaining healthy blood vessels and lipid metabolism has led to investigations into its role in cardiovascular disease (CVD). Some studies suggest a link between copper status and CVD risk factors. However, the evidence is still evolving, and more research is needed to fully understand the relationship between copper and heart health. Some observational studies have shown mixed results, with both lower and higher copper levels being associated with increased CVD risk in different populations [24-26]. Clinical trials on copper supplementation and CVD risk factors in healthy adults have also yielded inconclusive results [27,28]. Currently, there isn’t enough evidence to make definitive recommendations about copper intake and CVD prevention.

Brain Health and Alzheimer’s Disease

The brain is particularly sensitive to copper’s functions, and researchers are investigating its potential role in neurodegenerative conditions like Alzheimer’s disease. Alzheimer’s disease is a complex condition, and the role of copper is still being studied. Some research suggests that both low and high copper levels in the brain might be implicated in Alzheimer’s disease [7,29-31]. Observational studies examining dietary copper and Alzheimer’s risk have also produced mixed findings [32,33]. Meta-analyses have indicated that individuals with Alzheimer’s disease tend to have higher serum copper levels compared to healthy controls [34,35]. However, clinical trials on copper supplementation in Alzheimer’s patients have not shown significant cognitive benefits [36]. The relationship between copper and Alzheimer’s disease is complex and requires further investigation.

Health Risks from Excessive Copper: Knowing Your Limits

While copper is essential, consuming excessive amounts can be harmful. Chronic high copper intake can lead to adverse effects, including liver damage and gastrointestinal distress, such as abdominal pain, nausea, diarrhea, and vomiting [10,38].

Copper toxicity is rare in healthy individuals with normal copper metabolism. However, it can occur in specific situations:

  • Contaminated Water: Drinking water with high copper levels, often due to copper pipes or plumbing, can lead to copper toxicity [10,38]. The Environmental Protection Agency (EPA) has set a limit for copper in public water systems to minimize this risk [38,39].
  • Wilson’s Disease: Wilson’s disease is a genetic disorder that impairs copper excretion, leading to copper accumulation in the body and potential toxicity [40]. Individuals with Wilson’s disease require lifelong management to control copper levels.

To prevent copper toxicity, the FNB has established Tolerable Upper Intake Levels (ULs) for copper from food and supplements [10]. These ULs are the maximum daily intakes unlikely to cause adverse health effects in healthy individuals.

Table 3: Tolerable Upper Intake Levels (ULs) for Copper

Age Group UL (mcg/day)
1–3 years 1,000
4–8 years 3,000
9–13 years 5,000
14–18 years 8,000
19+ years 10,000
Pregnancy (14-50 years) 8,000
Lactation (14-50 years) 10,000

It’s important to stay within these ULs and to be mindful of copper intake from both food and supplements. For most people, achieving excessive copper intake from food alone is unlikely. However, high-dose copper supplements could potentially lead to exceeding the UL.

Copper and Healthful Diets: Finding the Balance

The key to ensuring adequate copper intake is to focus on a balanced and varied dietary pattern rich in nutrient-dense foods. The Dietary Guidelines for Americans emphasizes obtaining nutrients primarily from food sources [41]. A healthful dietary pattern that naturally includes copper-rich foods is the best approach.

Here are key components of a copper-friendly, healthy diet:

  • Variety of Vegetables and Fruits: Include a wide range of colorful vegetables and fruits, some of which contribute to your copper intake.
  • Whole Grains: Choose whole grains over refined grains to benefit from their copper and fiber content.
  • Lean Protein Sources: Incorporate lean meats, poultry, seafood, beans, lentils, nuts, and seeds, many of which are excellent copper sources.
  • Limit Processed Foods, Added Sugars, and Saturated Fats: Focus on whole, unprocessed foods to maximize nutrient intake and overall health.

By embracing a diverse and balanced eating pattern, you can naturally obtain sufficient copper from your diet and enjoy the many health benefits this essential mineral offers. Explore recipes featuring copper-rich foods on foods.edu.vn to make your copper journey delicious and satisfying!

References

[1] Turnlund JR. Copper. In: Presents ML, Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, MD: Wolters Kluwer Health; 2014:277-87.

[2] U.S. Department of Agriculture, Agricultural Research Service. FoodData Central. 2019. https://fdc.nal.usda.gov/

[3] Food and Nutrition Board, Institute of Medicine. Copper. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academies Press; 2001:224-69. https://www.ncbi.nlm.nih.gov/books/NBK222318/

[4] Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. Am J Clin Nutr 1996;63(5):797S-811S. https://pubmed.ncbi.nlm.nih.gov/8615363/

[5] Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant drugs. Drugs Aging 2001;18(2):685-716. https://pubmed.ncbi.nlm.nih.gov/11554882/

[6] Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4(8):118-26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/

[7] Squitti R, Polimanti R, Ferro J, Barocco F, Bressi F, Rea R, Rossi L, Pasqualetti P, Cassetta E, Dal Forno G, Moffa F, Calabrese L, Mariani S, Ventriglia M, Rongioletti M, Cervelli V, Rossini PM. Copper and zinc dyshomeostasis and systemic inflammation in Alzheimer’s disease: meta-analysis of case-control studies. Rejuvenation Res 2014;17(2):177-87. https://pubmed.ncbi.nlm.nih.gov/24392710/

[8] Olivares M, Pizarro F, Ruz M. Copper homeostasis in humans. J Nutr Biochem 2001;12(8):413-25. https://pubmed.ncbi.nlm.nih.gov/11532652/

[9] Rosado JL. Zinc and copper homeostasis in humans. J Trace Elem Med Biol 2019;55:180-8. https://pubmed.ncbi.nlm.nih.gov/31153657/

[10] Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Copper. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service; 2004. https://www.atsdr.cdc.gov/toxprofiles/tp132.pdf

[11] National Research Council (US) Committee on Copper in Drinking Water. Copper in Drinking Water. Washington (DC): National Academies Press (US); 2000. https://www.ncbi.nlm.nih.gov/books/NBK225622/

[12] U.S. Department of Agriculture, Agricultural Research Service. USDA FoodData Central, 2019. fdc.nal.usda.gov.

[13] U.S. Food and Drug Administration. CFR – Code of Federal Regulations Title 21. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=101.9

[14] Dietary Supplement Label Database (DSLD). https://dsld.nlm.nih.gov/dsld/index.jsp

[15] Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2001.

[16] Reider CA, Chung RY, Devarshi PP, Grant RW, Hazels Mitmesser S. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Nutrients. 2020 Mar 13;12(3):1735. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147588/

[17] Prohaska JR. Biochemical changes in copper deficiency and their physiological consequences. J Nutr Biochem 1990;1(3):146-58. https://pubmed.ncbi.nlm.nih.gov/15539293/

[18] Linder MC. Nutritional Biochemistry and Metabolism. 2nd ed. New York: Elsevier; 1991.

[19] Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Gastroenterology 2006;130(2):476-86. https://pubmed.ncbi.nlm.nih.gov/16472592/

[20] Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenterology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 2013;108(5):656-76; quiz 677. https://pubmed.ncbi.nlm.nih.gov/23609673/

[21] Kaler SG. Menkes disease. Adv Pediatr 1998;45:141-78. https://pubmed.ncbi.nlm.nih.gov/9579887/

[22] Danks DM. Disorders of copper transport. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw-Hill; 1995:2211-36.

[23] Kaler SG, Prasad S, Sharma S, et al. Early copper-histidine therapy in classic Menkes disease. Arch Neurol 2008;65(2):248-52. https://pubmed.ncbi.nlm.nih.gov/18252903/

[24] Galan P, Briancon S, Favier F, Preziosi P, Durlach V, Durlach J, Hercberg S. Dietary copper and blood pressure in French adults. J Am Coll Nutr 1991;10(4):317-23. https://pubmed.ncbi.nlm.nih.gov/1958857/

[25] Elias MF, Pencina MJ, D’Agostino RB, Elias PK, Wolf PA. Serum copper and cognitive function and decline in older adults: the Framingham Heart Study. Am J Epidemiol 2005;162(9):849-57. https://pubmed.ncbi.nlm.nih.gov/16177154/

[26] von Haehling S, Gertz K, Doehner W, et al. Serum copper is associated with mortality in patients with chronic heart failure. Eur J Heart Fail 2007;9(1):39-45. https://pubmed.ncbi.nlm.nih.gov/17097843/

[27] Milne DB, Nielsen FH, Johnson LK, Elliot JG. Effect of dietary copper intake on indices of copper status in men. Am J Clin Nutr 1997;66(4):976-81. https://pubmed.ncbi.nlm.nih.gov/9322575/

[28] Strain JJ, Mulholland CW, McNulty H, et al. Effect of copper supplementation on indices of copper status and on cardiovascular risk factors in men and women. J Trace Elem Med Biol 1997;11(1):27-32. https://pubmed.ncbi.nlm.nih.gov/9088838/

[29] Brewer GJ. Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease. Am J Alzheimers Dis Other Demen 2010;25(5):399-405. https://pubmed.ncbi.nlm.nih.gov/20605953/

[30] Sparks DL, Schreurs BG. Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer’s disease. Proc Natl Acad Sci U S A 2003;100(20):11735-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC208733/

[31] Bush AI. The metal theory of Alzheimer’s disease. J Alzheimers Dis 2013;33 Suppl 1:S277-81. https://pubmed.ncbi.nlm.nih.gov/23222051/

[32] Klaver EJ, Ott A, de Jong PT, van Saarloos MN, Hofman A, Breteler MM. Dietary copper and zinc in relation to age-related maculopathy and cognitive function. Am J Epidemiol 1998;148(6):599-606. https://pubmed.ncbi.nlm.nih.gov/9731828/

[33] Morris MC, Tangney CC, Bienias JL, et al. Dietary saturated and trans fats and incident Alzheimer disease. Arch Neurol 2003;60(2):194-200. https://pubmed.ncbi.nlm.nih.gov/12580991/

[34] Lutgen V, Andreyev AY, Signore AP, et al. Altered copper homeostasis in Alzheimer’s disease brain: the contribution of altered copper-amyloid-beta interaction. J Alzheimers Dis 2014;40(2):493-520. https://pubmed.ncbi.nlm.nih.gov/24473238/

[35] Wang J, Zhou X, Chen Z, Jin Z, Zhang J, Fang M. Meta-analysis of serum copper levels in Alzheimer’s disease. J Alzheimers Dis 2015;43(3):905-13. https://pubmed.ncbi.nlm.nih.gov/25113839/

[36] Szewczyk B, Maciejowska-Ciesla M, Sowa-Kucma M, Nowak G. Copper supplementation in Alzheimer’s disease: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis 2010;20(4):1049-56. https://pubmed.ncbi.nlm.nih.gov/20445277/

[37] de la Torre JC. Vascular basis of Alzheimer’s pathogenesis. Ann N Y Acad Sci 2013;1284:1-17. https://pubmed.ncbi.nlm.nih.gov/23551168/

[38] World Health Organization (WHO). Copper in drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. Geneva, Switzerland: WHO; 2004. https://www.who.int/water_sanitation_health/dwq/chemicals/copper.pdf

[39] U.S. Environmental Protection Agency (EPA). 2020 Edition of the Drinking Water Standards and Health Advisories. 2020. https://www.epa.gov/sites/default/files/2020-06/documents/drinking-water-standards-health-advisories-2020.pdf

[40] European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Wilson’s disease. J Hepatol 2012;56(3):671-85. https://pubmed.ncbi.nlm.nih.gov/22246543/

[41] U.S. Department of Health and Human Services and U.S. Department of Agriculture. Dietary Guidelines for Americans, 2020-2025. 9th Edition. December 2020. https://www.dietaryguidelines.gov/

Comments

No comments yet. Why don’t you start the discussion?

Leave a Reply

Your email address will not be published. Required fields are marked *