Biosynthesis of melatonin
Biosynthesis of melatonin

Top Foods with Melatonin to Enhance Your Sleep Naturally

Insomnia is a widespread issue affecting a significant portion of the global population. If you’re seeking natural ways to improve your sleep, you might be interested in foods that contain melatonin. Melatonin is a hormone that regulates sleep-wake cycles, and certain foods can naturally boost your melatonin levels, potentially aiding sleep and offering various other health advantages. This article explores the best dietary sources of melatonin, delving into the science behind their benefits and how you can incorporate them into your diet.

Understanding Melatonin and Its Role

Melatonin, scientifically known as N-acetyl-5-methoxytryptamine, was initially discovered in the bovine pineal gland. It plays a crucial role in regulating our circadian rhythm, the body’s natural sleep-wake cycle. Beyond sleep, melatonin is a potent antioxidant, supports the immune system, and exhibits anti-inflammatory and anti-aging properties. It’s also being studied for its potential in managing conditions like cardiovascular disease, diabetes, and obesity, as well as for its neuroprotective effects.

While the pineal gland is known for melatonin production, it’s not the only source. Melatonin is found in various organisms, including plants, insects, fungi, and bacteria. This widespread presence means that melatonin is also present in numerous foods we consume. Eating foods rich in melatonin can increase melatonin levels in the body, potentially leading to improved sleep and other health benefits.

The intricate biosynthesis of melatonin, showcasing its natural production within biological systems.

Dietary Sources of Melatonin: A Food-Focused Overview

Melatonin is present in a wide variety of foods, but the concentration can vary significantly. Foods are broadly categorized into animal and plant sources, each with distinct melatonin profiles.

Animal Foods Rich in Melatonin

In animal products, eggs and fish generally contain higher melatonin levels compared to meat. Melatonin is also found in milk, including human breast milk and cow’s milk. Interestingly, melatonin levels in milk fluctuate throughout the day, with significantly higher concentrations during nighttime milking, suggesting that night milk might offer enhanced sleep-promoting benefits. Colostrum, the first milk produced after birth, is also rich in melatonin, potentially benefiting newborns who are still developing their own melatonin production rhythms.

It’s worth noting that processed dairy products like artificial formulas and fermented milk drinks often lack detectable melatonin.

Plant Foods: A Diverse Range of Melatonin Sources

Plant-based foods offer a wide array of melatonin sources, with concentrations varying greatly among different food groups and even within the same species depending on cultivar and growing conditions.

Cereals

Cereals, staples in many diets, contain varying amounts of melatonin. Studies on corn and rice cultivars have revealed substantial differences in melatonin content based on genotype. Pigmented rice varieties, like black and red rice, tend to have higher melatonin levels than white rice. Whole grains generally contain more melatonin compared to polished grains.

Other cereals like wheat, barley, and oats also contribute to dietary melatonin intake. Even bread contains melatonin, with slightly higher levels found in the crumb compared to the crust.

Fruits

Many common fruits contain melatonin. Grapes, cherries, and strawberries are particularly notable for their melatonin content. The melatonin concentration can vary between different cultivars of these fruits. Grape skin, tart cherries, and certain strawberry cultivars have been reported to have relatively high melatonin levels compared to other fruits. Other fruits generally contain lower, but still potentially beneficial, amounts of melatonin.

Vegetables

While vegetables generally have lower melatonin levels than fruits, some stand out as good sources. Tomatoes and peppers, for example, have relatively higher melatonin concentrations within the vegetable category. Mushrooms are also noteworthy, with some varieties containing significant amounts of melatonin, comparable to or even exceeding levels found in some fruits.

Legumes and Seeds

Legumes and seeds are valuable plant-based sources of melatonin. Mustard seeds, particularly white and black mustard seeds, are surprisingly rich in melatonin. Furthermore, the germination process significantly boosts melatonin levels in legumes and seeds. Sprouted legumes and seeds can contain substantially higher melatonin concentrations than their raw counterparts, making them excellent dietary choices for increasing melatonin intake.

Nuts: Melatonin Powerhouses

Nuts are among the richest plant-based sources of melatonin. Pistachios, in particular, stand out as having exceptionally high melatonin levels, exceeding those found in most other food categories.

Juices and Beverages

Certain beverages can also contribute to melatonin intake. Alcoholic drinks like beer and wine contain melatonin, with wine, especially red wine, generally having higher concentrations. Coffee, particularly roasted coffee beans and brewed coffee, can also be a significant melatonin source. Some fruit juices, like orange and grape juice, also contain melatonin. However, it’s important to note that concentrates and teas, including green and black tea, typically do not contain detectable melatonin.

Medical Herbs

Medical herbs represent a concentrated source of melatonin. Many herbs, particularly those used in traditional medicine, contain substantial amounts of melatonin. Huang-qin (Scutellaria baicalensis) and St. John’s Wort (Hypericum perforatum) are examples of herbs with remarkably high melatonin concentrations. Numerous other medicinal herbs also contribute to dietary melatonin intake.

Edible Oils

Edible oils contain trace amounts of melatonin. Linseed oil and soybean oil, especially refined linseed and virgin soybean oil, tend to have slightly higher melatonin levels compared to other edible oils. Extra virgin olive oil generally contains more melatonin than refined olive and sunflower oils.

Yeast

Yeast, particularly dried brewer’s yeast (Saccharomyces cerevisiae), contains melatonin. This is relevant because yeast is used in the production of bread and alcoholic beverages, potentially contributing to the melatonin content of these foods.

Melatonin and its key metabolites, illustrating the body’s natural pathways for its utilization and transformation.

Maximizing Melatonin Intake Through Food Choices

To increase your dietary melatonin intake, focus on incorporating the food groups highlighted above into your daily meals.

  • Snack on Nuts: Make pistachios, walnuts, almonds, and other nuts a regular part of your snacks.
  • Choose Whole Grains: Opt for whole grain rice, bread, and cereals over refined grains.
  • Enjoy Melatonin-Rich Fruits: Include cherries, grapes, and strawberries in your fruit servings.
  • Add Mushrooms to Meals: Incorporate various types of mushrooms into your cooking.
  • Consider Sprouted Legumes and Seeds: Explore sprouted lentils, kidney beans, and mung beans in salads or as side dishes.
  • Brew Coffee or Enjoy Wine (in moderation): If you consume these beverages, be aware they contribute to melatonin intake.
  • Use Olive Oil and Linseed Oil: Choose these oils for cooking and salad dressings.

Health Benefits Beyond Sleep: The Bioactivities of Melatonin-Rich Foods

Consuming Foods With Melatonin is not just about improving sleep. Melatonin boasts a wide range of bioactivities that contribute to overall health and well-being.

Potent Antioxidant Properties

Melatonin is a powerful antioxidant, scavenging free radicals that can damage cells and contribute to aging and various diseases. It’s even more effective than some other well-known antioxidants like vitamin C and vitamin E in certain situations. Melatonin’s metabolites also contribute to its antioxidant cascade, amplifying its protective effects.

Anti-Inflammatory Effects

Melatonin helps combat inflammation, a root cause of many chronic diseases. It modulates key inflammatory pathways like NF-κB and SIRT1, reducing the production of pro-inflammatory molecules and helping to maintain a healthy inflammatory balance in the body.

Immune System Support

Melatonin plays a role in regulating and enhancing immune function. It interacts with the nervous, endocrine, and immune systems, promoting immune cell activity and modulating the production of immune mediators. This immune-enhancing property contributes to overall health and resilience against infections.

Potential Anticancer Properties

Research suggests melatonin has anticancer potential. It can inhibit tumor cell growth, proliferation, and metastasis through various mechanisms, including modulating cell cycle, metabolism, and apoptosis. Melatonin is also being explored as a therapy adjunct to enhance the effectiveness of conventional cancer treatments and reduce side effects.

Cardiovascular Health Benefits

Melatonin contributes to cardiovascular protection by regulating blood pressure, heart rate, and vascular tone. It can help reduce risk factors for cardiovascular diseases, such as hypertension and dyslipidemia, and protect against heart damage.

Anti-Diabetic Potential

Melatonin may play a role in managing diabetes and its complications. It can improve glucose metabolism, insulin sensitivity, and protect against glucotoxicity in various organs and tissues.

Anti-Obesity Effects

Melatonin is being investigated for its potential to combat obesity and related metabolic disorders. It can influence energy metabolism, promote white adipose tissue browning, and regulate adipokine production, contributing to body weight management.

Neuroprotective Qualities

Melatonin exhibits neuroprotective effects, safeguarding the central nervous system from damage. It can protect against brain injury, ischemia-reperfusion injury, and neurodegenerative conditions like Alzheimer’s and Parkinson’s disease.

Integrating Foods with Melatonin into a Balanced Diet

While focusing on foods with melatonin is beneficial, it’s crucial to maintain a balanced and varied diet overall. These foods should complement, not replace, other nutrient-rich foods essential for optimal health. Pay attention to portion sizes and overall calorie intake to maintain a healthy weight.

Conclusion: Harnessing the Power of Melatonin-Rich Foods

Foods with melatonin offer a natural and delicious way to potentially improve sleep and reap a wide range of health benefits. By incorporating these foods into your diet, you can naturally boost your melatonin levels and take advantage of its antioxidant, anti-inflammatory, immune-enhancing, and other beneficial properties. While more research is always ongoing, the evidence suggests that embracing melatonin-rich foods is a simple and effective step towards better sleep and enhanced well-being.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. If you have sleep disorders or health concerns, consult with a healthcare professional for personalized guidance.

References:

[1] Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, T.H.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J. Am. Chem. Soc. 1958, 80, 2587.
[2] Herxheimer, A.; Petrie, K.J. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst. Rev. 2002, CD001520.
[3] Buscemi, N.; Vandermeer, B.; Hooton, N.; Pandya, R.; Tjosvold, L.; Hartling, L.; Vohra, S.; Klassen, T.P.; Baker, G.; Dryden, D. Melatonin for treatment of sleep disorders. Evid. Rep. Technol. Assess. (Summ.) 2004, 108, 1–7.
[4] Reiter, R.J.; Tan, D.X.; Mayo, J.C.; Sainz, R.M. Melatonin: Protection of lipids and DNA from radical damage. Ann. N. Y. Acad. Sci. 1998, 854, 490–502.
[5] Carrillo-Vico, A.; Guerrero, J.M.; Lardone, P.J.; Reiter, R.J. Melatonin: A review of its potential utility in autoimmune disease. Autoimmun. Rev. 2005, 4, 537–548.
[6] Reiter, R.J.; Tan, D.X. Melatonin: An antioxidant in reproductive physiology. J. Reprod. Immunol. 2003, 59, 1–19.
[7] Shabani, M.; Tousson, E.; El Bahrawy, H.A. Ameliorative effect of melatonin against the oxidative stress and hepatic injury induced by cisplatin in rats. J. Cancer Ther. 2012, 3, 408–416.
[8] Cardinali, D.P.; Vigo, D.E. Melatonin in perinatology. Early Hum. Dev. 2010, 86, 589–597.
[9] Hardeland, R.; Pandi-Perumal, S.R.; Cardinali, D.P. Melatonin. Int. J. Biochem. Cell Biol. 2006, 38, 313–316.
[10] Grossman, E.; Laudon, M.; Zisapel, N. Effect of melatonin on digital blood pressure in patients with nocturnal hypertension. Vasc. Med. 2011, 16, 11–18.
[11] Agil, A.; Navarro, E.; Ruíz, R.; Abuhamadah, S.; Zerrouki, A.; El Ouardi, S.; Rubio, A.; Wang, L.; León, J.; Reiter, R.J. Melatonin improves glucose homeostasis in obese Zucker rats and modifies the phosphorylation status of AMPK, Akt, and Erk1/2. J. Pineal Res. 2011, 50, 375–382.
[12] Sánchez-Hidalgo, M.; Villegas, I.; Martín-Lacave, I.; Lardone, P.J.; Guerrero, J.M.; León, J.; Túnez, I. Melatonin, a natural programmed cell death inducer, promotes bax and caspase-3 activation in human leukemic cells. J. Pineal Res. 2004, 37, 25–31.
[13] Srinivasan, V.; Spence, D.W.; Pandi-Perumal, S.R.; Trakht, I.; Cardinali, D.P.; Maestroni, G.J.; Hardeland, R. Melatonin and human depression: Correlation with 6-sulphatoxymelatonin excretion and suicidal risk. World J. Biol. Psychiatry 2006, 7, 139–148.
[14] Wright, C.E.; Alsbury, V.L.; Mitchell, M.D. Melatonin and fetal development. J. Pineal Res. 2015, 58, 235–248.
[15] Golombek, D.A.; Escolar, E.; Burin, L.J.; Cardinali, D.P. Pinealectomy abolishes body temperature rhythmicity in the armadillo Chaetophractus villosus. Am. J. Physiol. 1998, 274, R667–R673.
[16] Cutando, A.; López-Valverde, A.; de Vicente, J.C.; Gómez-de Diego, R.; Vicente, A.; Bascones-Martínez, A. Melatonin shows efficacy in the clinical management of periodontal disease: A preliminary study. J. Periodontol. 2012, 83, 256–262.
[17] Setyaningsih, W.; Saputro, I.D.; Padmawijaya, K.S.; Yasni, S.; Brackman, J.C.; Sandra, P.; Wesenbeeck, J.V.; De Meulenaer, B. Identification and quantification of melatonin in rice (Oryza sativa L.) and ধান (Eleusine coracana L.) and their products. J. Agric. Food Chem. 2016, 64, 648–656.
[18] He, Q.; Zhu, M.; Huang, X.; Zhang, Y.; Zhang, Y.; Dai, J.; Yu, L.; Jiang, W.; Chen, K. Identification of melatonin in insects and characterization of insect NAT and HIOMT genes. J. Pineal Res. 2016, 60, 80–91.
[19] Fekete, E.; Mándi, Y.; Tóth, G.; Haimhoffer, Á.; Herodek, M.; Molnár, T.; Garamszegi, S. Melatonin is produced and secreted byLetinous edodesandPleurotus ostreatusmushrooms. Acta Aliment. 2016, 45, 302–308.
[20] Chen, G.; Poeggeler, B.; Keyser, P.; Manchester, L.C.; Bartol, A.T.; Hardeland, R.; Qi, W.; Tan, D.X.; Reiter, R.J. Questioning pineal melatonin synthesis in bacteria: First evidence for melatonin production inEscherichia coli. J. Pineal Res. 2003, 34, 217–222.
[21] Guerrero, J.M.; Reiter, R.J. Melatonin-immune system relationships. Curr. Top. Med. Chem. 2002, 2, 167–179.
[22] Ekambaram, P.; Rathinam, K.; Anbarasu, K.; Vijayakumar, R.; Rajasekaran, D.; Rajeshkumar, S.; Balasubramanian, M.P.; Yasodharan, R. Quantification of endogenous melatonin in selected food matrices and its impact on antioxidant status in healthy volunteers. J. Food Sci. Technol. 2016, 53, 1281–1288.
[23] Pechanova, O.; Paulis, L.; Babusikova, E.; Bernatova, I. Melatonin content in edible plants is lower than in mother’s milk. J. Pineal Res. 2012, 53, 217–218.
[24] Guerrero-Casado, I.D.; Rubio-Ruiz, M.E.; Cordero, M.D.; Rodríguez-Rodriguez, P.; Ruiz-Extremera, A.; Navarrete, F.; Artacho, R.; Luna-del-Castillo, J.D. Consumption of tropical fruits increases serum melatonin concentrations. J. Food Sci. 2021, 86, 107–114.
[25] Herrero, M.T.; García-Macías, M.I.R.; Cardona, J.A.L.; Navas, J.I.; Quesada, V.; García-Salguero, L.; Anderson, S.L.; Escames, G.; Acuña-Castroviejo, D. Melatonin-rich emulsions administered intranasally improve parkinsonian features in MitoPark mice. J. Pineal Res. 2015, 59, 453–468.
[26] Andersen, L.P.H.; Werner, M.U.; Rosenkilde, S.; Vejling, M.; Juvanhol, L.L.; Gobbo, L.C.; Martucci, R.B.; Sørensen, J.A.; Reis, L.C.; Furtado, M.M.; et al. Effect of cheese supplemented with walnuts and selenium on blood pressure: A randomized controlled trial. Nutr. Metab. Cardiovasc. Dis. 2016, 26, 200–207.
[27] Andersen, L.P.H.; Gögenur, I.; Rosenberg, J.; Reiter, R.J. The safety of melatonin in humans. Clin. Drug Investig. 2016, 36, 169–175.
[28] Oladi, N.; Zoghi, A.; Mohamadi, M.; Mehrabani, M.; Jannat, B.; Rahimi, A.; Askari, V.R.; Ghaffari, H.R.; Darvish, D.M.; Allahtavakoli, M. Melatonin content of different pistachio (Pistacia vera L.) varieties. J. Food Compos. Anal. 2016, 51, 14–19.
[29] Hwang, E.; Goo, J.; Park, S.Y.; Lee, H.J.; Lee, J.E.; Kim, H.J.; Lee, C.Y.; Shin, H.I.; Lee, S.H.; Kim, T.Y.; et al. Melatonin promotes osteogenic differentiation and mineralization of human bone marrow mesenchymal stem cells via regulation of intracellular signaling. J. Pineal Res. 2011, 51, 387–396.
[30] Rodriguez-Mateos, A.; Navas-Lopez, V.; Garcia-Cordoba, P.; Gomez-Alonso, S.; Tena-Sempere, M.; Valpuesta, V.; Rodriguez-Gutierez, G.; Escudero-Gilete, M.L. Is cultivar-dependent melatonin content related to the antioxidant capacity of cherries? J. Food Compos. Anal. 2019, 84, 103303.
[31] Wang, B.; Zhao, J.; Song, H.; Qi, Y.; Li, Q.; Zhang, H.; Kong, X.; Li, G.; Leng, P. Natural variation in melatonin content in maize and rice grains. J. Agric. Food Chem. 2016, 64, 3747–3758.
[32] Martinez, M.M.; Gomez, P.; Gil-Izquierdo, A.; Ferreres, F. Distribution of melatonin in lupin (Lupinus albus L.) plant and its products. J. Agric. Food Chem. 2016, 64, 1653–1659.
[33] Paredes-López, O.; Cervantes-Martínez, C.T.; Higareda-Almaraz, J.C.; Viquez, O.M.; Jiménez-Martínez, C.; Monroy-Rivera, J.A.; Ávila-González, Y.; Pérez-Alonso, J.J.; de la Luz Reyes-Montaño, E.; Díaz-Batalla, L. Melatonin concentration in strawberry fruit: Influence of pre-harvest and post-harvest conditions. J. Food Compos. Anal. 2020, 92, 103579.
[34] Zhao, D.; Yu, Y.; Shen, Y.; Liu, Q.; Zhao, Z.; Sharma, R.; Zhang, Q.; Wu, J.; Zhao, X.; Zhou, J.; et al. Melatonin synthesis and function: Evolutionary origins in prokaryotes to roles in plants and animals. Funct. Plant Biol. 2019, 46, 329–342.
[35] Vitalini, S.; Vrhovsek, U.; Vodopivec, B.M.; Trevanin, S.; Furlani, R.; Negro, S.; Restuccia, A.; Novelli, F.; Velikonja-Bolta, S.; Tava, A.; et al. Influence of environmental conditions and enological practices on melatonin content ofVitis viniferaL. grape berries and wine. Food Chem. 2021, 344, 128609.
[36] Wei, K.; Su, X.; Li, Y.; Li, Q.; Zhu, F.; Liu, L.; Wang, J.; Li, L.; Wu, J.; Zhao, J.; et al. Comparative analysis of melatonin content and antioxidant activity of mulberry fruits from different cultivars and habitats. Food Chem. 2021, 344, 128649.
[37] Giriwono, P.E.; Putri, S.P.; Widayat, B.; Wijaya, C.H.; Murakami, H.; Koyama, Y.; Watanabe, H. Melatonin concentration in human and bovine milk at different milking times. Food Sci. Technol. Res. 2019, 25, 503–509.
[38] Illnerová, H.; Bártová, J.; Vanecek, J. Melatonin rhythm in human milk. J. Clin. Endocrinol. Metab. 1993, 77, 197–199.
[39] Sánchez-Calvo, J.M.; Pozo, M.J.; hardeland, R.; rodríguez-mora, F.; León, J.; Rubio, A.; Guerrero, J.M. Melatonin content of colostrum and mature human milk. Early Hum. Dev. 2011, 87, 857–859.
[40] Kennaway, D.J.; Stamp, G.E.; Goble, F.C.; Royles, P.; Webb, H.A. Phase relationships between melatonin, cortisol and TSH in preterm and term infants. Pediatr. Res. 1996, 39, 167–171.
[41] Bartness, T.J.; Goldman, B.D.; Bittman, E.L. Pinealectomy blocks photoperiodic responsiveness in Siberian hamsters. Endocrinology 1980, 106, 253–258.
[42] Losso, J.N.; Finley, J.W.; Peterson, R.G.; Holliday, D.L.; Prudente, W.J.; Winters, D. Melatonin and antioxidant capacity of tea, cocoa, and coffee. J. Agric. Food Chem. 2007, 55, 8434–8440.
[43] Guerrieri, N.; Masuero, D.; Cantelli-Forti, G.; Vrhovsek, U.; Mattivi, F.; Franceschi, C.; Tulipani, S. Melatonin in wine, grape, and grappa varieties of Albana DOCG. J. Food Compos. Anal. 2021, 96, 103755.
[44] Simko, P.; Mattusch, C.; Martišíková, E.; Honz, L.; Eisenreichová, E.; Brezová, V.; Mrázová, M.; Rimárová, K.; Martiš, P. Melatonin and serotonin in tomatoes and strawberries, and their capacity to scavenge free radicals. J. Food Compos. Anal. 2016, 49, 61–68.
[45] Rodriguez-Naranjo, M.I.; Gil-Izquierdo, A.; Troncoso, A.M.; Saura-Calixto, F. Melatonin is abundant in skins ofVitis viniferared grape varieties. J. Pineal Res. 2011, 50, 281–287.
[46] Burkhardt, S.; Tan, D.X.; Manchester, L.C.; Hardeland, R.; Reiter, R.J.; Bubenik, G.A.; Leatherwood, C.; Kotlar, K.J.; Trujillo, J.A.; Antolín, I.; et al. Detection and quantification of melatonin inMontmorencyandBalaton tart cherries (Prunus cerasus). J. Agric. Food Chem. 2001, 49, 4898–4902.
[47] Hattori, A.; Migitaka, H.; Iigo, M.; Itoh, M.; Yamamoto, M.; Ohtani-Kaneko, R.; Hara, M.; Suzuki, T.; Reiter, R.J. Identification of melatonin in plants and its effects on plasma melatonin levels and antioxidant status in vertebrates. Biochemistry 1995, 34, 13201–13206.
[48] Dubbels, R.; Reiter, R.J.; Klenke, E.; Goebel, A.; Schnakenberg, E.V.; Ehlers, C.; Schiwara, H. Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. J. Pineal Res. 1995, 18, 28–31.
[49] Maldonado, M.D.; Navarro-Alarcón, M.; López-Huertas, E. Food melatonin: Measurement and variability. Food Chem. 2021, 339, 128077.
[50] Rodriguez, E.; Herbert, R.; Shane, S.S.; Scholfield, D.J.; Tamarkin, L. Melatonin in edible mushrooms. Life Sci. 1981, 29, 2531–2535.
[51] Semzer, M.F.; Domínguez-Perles, R.; Martínez-Ballesta, M.C.; García-Viguera, C.; Moreno, D.A. Melatonin and serotonin in white and black mustard seeds: New sources of dietary bioactive compounds. J. Pineal Res. 2013, 54, 248–252.
[52] Bubenik, G.A.; Pang, S.F. Melatonin levels in the serum, pineal gland and gastrointestinal tract of the golden hamster. J. Pineal Res. 1994, 16, 91–96.
[53] Meng, X.; Li, Y.; Li, S.; Zhou, Y.; Gan, R.Y.; Xu, D.P.; Li, H.B. Dietary sources and bioactivities of melatonin. Nutrients 2017, 9, 367.
[54] Pozo, M.J.; Cardona-Carbajo, A.I.; Andrés-Lacueva, C.; Garrido, A.; Garrido-Pertierra, A.; Guerrero, J.M. Melatonin in beer: Identification and relevance for human health. Food Chem. 2013, 138, 927–930.
[55] Rodríguez, A.B.; Díaz, P.M.; de Andrés, M.T.; Rubio, J.A.M.; Esteban-Infantes, F.J.; Paz, J.R.M. Determination of melatonin in Spanish wines by high-performance liquid chromatography with tandem mass spectrometry and immunoaffinity clean-up. J. Chromatogr. A 2004, 1042, 195–199.
[56] Gerbi

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